6.09.2009

Weill and Columbia Scientists Announce Transgenic Mouse Model
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Scientists from Columbia and Cornell have announced a new Transgenic mouse model version relating to Parkinson's Disease. Here's the abstract from Nature Neuroscience:

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.


The Full article is here

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