APOEe4 May Be Associated with Unsuccessful Aging

A study of APOE3 and 4 gene carriers compared with APOE2 and 3 found a greater incidence of mortality in the former amongst a population in Sicily.

The researchers suggest that APOEe4 therefore, can be linked with "early, unsuccessful aging" and present Down Syndrome as a model for this declination of longevity. By studying Down Syndrome carefully, more insight can be gathered into how APOEe4 cuts short longevity. It's suggested that vascular problems play a role along with higher incidence of Alzheimer's Disease.

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