12.07.2005

Yin and Yang Protein in Alzheimer's
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Cognitive Labs newswire....

Researchers have found evidence that may partially exonerate a protein known to be a culprit in the progression of Alzheimer's disease. Their new studies show that the protein p25, which wreaks havoc in the brains of patients with Alzheimer's disease, also has a good side in promoting the plasticity of the brain.

In studies in mice, the scientists have shown that the enzyme promotes structural changes in the brain associated with learning and memory. The studies indicate that when the concentration of the protein reaches excessive levels, it contributes to the brain cell death associated with Alzheimer's disease (AD). Their discovery of the dual nature of p25 suggests that drugs that partially inhibit p25's target enzyme could protect the neurons of patients with AD.


"We think there is a very intriguing possibility that p25 is normally produced at a low level in the brain, perhaps to maintain synaptic plasticity." Li-HueiTsai

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